A continuum crystal plasticity model is used to simulate the material behavior of a directionally solidified Ni-base superalloy, DS GTD-111, in the longitudinal and transverse orientations. Isothermal uniaxial fatigue tests with hold times and creep tests are conducted at temperatures ranging from room temperature (RT) to to characterize the deformation response. The constitutive model is implemented as a User MATerial subroutine (UMAT) in ABAQUS (2003, Hibbitt, Karlsson, and Sorensen, Inc., Providence, RI, v6.3) and a parameter estimation scheme is developed to obtain the material constants. Both in-phase and out-of-phase thermo-mechanical fatigue tests are conducted. A physically based model is developed for correlating crack initiation life based on the experimental life data and predictions are made using the crack initiation model.