Knowledge of the stress response of a material to the applied deformations is necessary for many engineering analysis and applications. This paper addresses the observed effects of load sequencing, Mullins effect, and multiaxial loading on the constitutive behavior of rubber under variable amplitude conditions for a series of experiments using multiaxial ring test specimens. Two filled rubber materials were used and compared in this study; natural rubber, which strain crystallizes, and styrene butadiene rubber (SBR), which does not. A pseudoelastic approach is used to model the cyclic stress-strain response for both materials. The implications of inelasticity when using hyperelastic material models are also discussed. Based on temperature results for the multiaxial ring specimen obtained via a thermal imaging system for SBR, a model capable of accurately predicting surface temperature for the multiaxial ring specimen as a function of hysteresis area and test frequency has been developed.