This paper reports the results obtained in a study on the effect of the addition of TiO2 nanoparticles on the mechanical properties and microstructural characteristics of photocatalytic concretes. In the hardened state, tests to determine the compressive strength and modulus of elasticity were carried out. Also, microstructural aspects of the samples were investigated. In the fresh state, the influence of the addition of TiO2 on the concrete compaction and conduction calorimetry curves was evaluated. The results obtained indicated a better mechanical and microstructural behavior of concrete with addition of TiO2.