The aim of this work is to design a lightweight, creep-resistant blade for an axial single-stage micro-gas turbine. The selected process was casting of an intermetallic titanium/aluminum alloy. All the project phases are described, from the preliminary thermodynamic and geometric stage design, to its three-dimensional (3D) modeling and the subsequent finite element method–computational fluid dynamics (FEM-CFD) analysis, to the manufacturing process of the single rotor blade. The blade making (height 7 cm and chord 5 cm, approximately) consisted in a prototyping phase in which a fully 3D version was realized by means of fused deposition modeling and then in the actual production of a full-scale set of blades by investment casting in an induction furnace. The produced items showed acceptable characteristics in terms of shape and soundness. Metallographic investigations and preliminary mechanical tests were performed on the blade specimens. The geometry was then refined by a CFD study, and a slightly modified shape was obtained whose final testing under operative conditions is though left for a later study. This paper describes the spec-to-final product procedure and discusses some critical aspects of this manufacturing process, such as the considerable reactivity between the molten metal and the mold material, the resistance of the ceramic shell to the molten metal impact at high temperatures, and the maximal acceptable mold porosity for the specified surface finish. The CFD results that led to the modification of the original commercial shape are also discussed, and a preliminary performance assessment of the turbine stage is presented and discussed.