Despite the strong consensus behind the need for an interoperable Healthcare Information System (HIS), the universal acceptance of a standard HIS framework has advanced very little and is yet to become a market reality. In an effort to advance this endeavor, this work provides a systematic comparison regarding two of the most relevant HIS frameworks recently proposed: The Integrated Clinical Environment (ICE) and the Healthcare Industry 4.0 Framework. The paper analyzes their differences and similarities and proposes a minimum set of requirements for prospective interoperable HIS architectures compliant with the Industry 4.0 design principles, goal-setting pillars, as well as support for closed-loop physiological systems. Finally, the paper discusses future works in the field.

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