Age-associated alterations in cardiovascular structure and function induce cardiovascular disease in elderly subjects. To investigate the effects of normal vascular aging (NVA) and early vascular aging (EVA) on hemodynamic characteristics in the circle of Willis (CoW), a closed-loop one-dimensional computational model was developed based on fluid mechanics in the vascular system. The numerical simulations revealed that higher central pulse pressure and augmentation index (AIx) appear in the EVA subjects due to early arrival of reflected waves, resulted in the increase of cardiac afterload compared with the NVA subjects. Moreover, the hemodynamic characteristics in the CoW show that the EVA subjects in an older age display a higher blood pressure than that of the NVA with a complete CoW. Herein, the increased blood pressure and flow rate coexist in the subjects with an incomplete CoW. In conclusion, the hemodynamic characteristics in the aortic tree and CoW related to aging appear to play an important role in causing cardiovascular and intravascular disease.
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June 2016
Research-Article
The Influence of Normal and Early Vascular Aging on Hemodynamic Characteristics in Cardio- and Cerebrovascular Systems
Hongtao Yu,
Hongtao Yu
Department of Mechanical and
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Yu.41@wright.edu
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Yu.41@wright.edu
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George P. Huang,
George P. Huang
Fellow ASME
Department of Mechanical and Materials
Engineering,
Wright State University,
Dayton, OH 45435
e-mail: George.huang@wright.edu
Department of Mechanical and Materials
Engineering,
Wright State University,
Dayton, OH 45435
e-mail: George.huang@wright.edu
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Zifeng Yang,
Zifeng Yang
Department of Mechanical and
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Zifeng.yang@wright.edu
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Zifeng.yang@wright.edu
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Fuyou Liang,
Fuyou Liang
School of Naval Architecture,
Ocean and Civil Engineering,
Shanghai Jiao Tong University,
800 Dongchuan Road,
Shanghai 200240, China
e-mail: Fuyouliang@sjtu.edu.cn
Ocean and Civil Engineering,
Shanghai Jiao Tong University,
800 Dongchuan Road,
Shanghai 200240, China
e-mail: Fuyouliang@sjtu.edu.cn
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Bryan Ludwig
Bryan Ludwig
Boonshoft School of Medicine,
Wright State University,
Dayton, OH 45435;
Wright State University,
Dayton, OH 45435;
Department of Neurology—Division of
NeuroInterventional Surgery,
Wright State University/Premier Health-Clinical
Neuroscience Institute,
30 East Apple Street,
Dayton, OH 45409
e-mail: Brludwig@PremierHealth.com
NeuroInterventional Surgery,
Wright State University/Premier Health-Clinical
Neuroscience Institute,
30 East Apple Street,
Dayton, OH 45409
e-mail: Brludwig@PremierHealth.com
Search for other works by this author on:
Hongtao Yu
Department of Mechanical and
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Yu.41@wright.edu
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Yu.41@wright.edu
George P. Huang
Fellow ASME
Department of Mechanical and Materials
Engineering,
Wright State University,
Dayton, OH 45435
e-mail: George.huang@wright.edu
Department of Mechanical and Materials
Engineering,
Wright State University,
Dayton, OH 45435
e-mail: George.huang@wright.edu
Zifeng Yang
Department of Mechanical and
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Zifeng.yang@wright.edu
Materials Engineering,
Wright State University,
Dayton, OH 45435
e-mail: Zifeng.yang@wright.edu
Fuyou Liang
School of Naval Architecture,
Ocean and Civil Engineering,
Shanghai Jiao Tong University,
800 Dongchuan Road,
Shanghai 200240, China
e-mail: Fuyouliang@sjtu.edu.cn
Ocean and Civil Engineering,
Shanghai Jiao Tong University,
800 Dongchuan Road,
Shanghai 200240, China
e-mail: Fuyouliang@sjtu.edu.cn
Bryan Ludwig
Boonshoft School of Medicine,
Wright State University,
Dayton, OH 45435;
Wright State University,
Dayton, OH 45435;
Department of Neurology—Division of
NeuroInterventional Surgery,
Wright State University/Premier Health-Clinical
Neuroscience Institute,
30 East Apple Street,
Dayton, OH 45409
e-mail: Brludwig@PremierHealth.com
NeuroInterventional Surgery,
Wright State University/Premier Health-Clinical
Neuroscience Institute,
30 East Apple Street,
Dayton, OH 45409
e-mail: Brludwig@PremierHealth.com
1Corresponding author.
Manuscript received January 6, 2016; final manuscript received March 21, 2016; published online April 11, 2016. Assoc. Editor: Tim David.
J Biomech Eng. Jun 2016, 138(6): 061002 (10 pages)
Published Online: April 11, 2016
Article history
Received:
January 6, 2016
Revised:
March 21, 2016
Citation
Yu, H., Huang, G. P., Yang, Z., Liang, F., and Ludwig, B. (April 11, 2016). "The Influence of Normal and Early Vascular Aging on Hemodynamic Characteristics in Cardio- and Cerebrovascular Systems." ASME. J Biomech Eng. June 2016; 138(6): 061002. https://doi.org/10.1115/1.4033179
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