Cardiovascular diseases (CVD) are the most prevalent cause of death in the Western World, and their prevalence is only expected to rise. Several screening modalities aim at detecting CVD at the early stages. A common target for early screening is common carotid artery (CCA) stiffness, as reflected in the pulse wave velocity (PWV). For assessing the CCA stiffness using ultrasound (US), one-dimensional (1D) measurements along the CCA axis are typically used, ignoring possible boundary conditions of neck anatomy and the US probe itself. In this study, the effect of stresses and deformations induced by the US probe, and the effect of anatomy surrounding CCA on a simulated 1D stiffness measurement (PWVus) is compared with the ground truth stiffness (PWVgt) in 60 finite-element models (FEM) derived from anatomical computed tomography (CT) scans of ten healthy male volunteers. Based on prior knowledge from the literature, and from results in this study, we conclude that it is safe to approximate arterial stiffness using 1D measurements of compliance or pulse wave velocity, regardless of boundary conditions emerging from the anatomy or from the measurement procedure.
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March 2019
Research-Article
Effect of Local Neck Anatomy on Localized One-Dimensional Measurements of Arterial Stiffness: A Finite-Element Model Study
Adriaan Campo,
Adriaan Campo
Ultrasound Elasticity Imaging Laboratory,
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032;
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032;
Laboratory of Biomedical Physics,
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.339,
Antwerp 2020, Belgium
e-mail: adriaan.campo@ua.ac.be
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.339,
Antwerp 2020, Belgium
e-mail: adriaan.campo@ua.ac.be
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Matthew D. McGarry,
Matthew D. McGarry
Thayer School of Engineering Dartmouth,
14 Engineering Drive,
Hanover, NH 03755
e-mail: matthew.d.mcgarry@dartmouth.edu
14 Engineering Drive,
Hanover, NH 03755
e-mail: matthew.d.mcgarry@dartmouth.edu
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Thomas Panis,
Thomas Panis
Radiology Department,
University Hospital of Brussels,
UZ Brussel, Campus Jette, Laarbeeklaan 101,
Brussels B-1090, Belgium
e-mail: Thomas.panis@gmail.com
University Hospital of Brussels,
UZ Brussel, Campus Jette, Laarbeeklaan 101,
Brussels B-1090, Belgium
e-mail: Thomas.panis@gmail.com
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Joris Dirckx,
Joris Dirckx
Laboratory of Biomedical Physics,
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.342,
Antwerp 2020, Belgium
e-mail: joris.dirckx@ua.ac.be
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.342,
Antwerp 2020, Belgium
e-mail: joris.dirckx@ua.ac.be
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Elisa Konofagou
Elisa Konofagou
Ultrasound Elasticity Imaging Laboratory,
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032
e-mail: ek2191@columbia.edu
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032
e-mail: ek2191@columbia.edu
Search for other works by this author on:
Adriaan Campo
Ultrasound Elasticity Imaging Laboratory,
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032;
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032;
Laboratory of Biomedical Physics,
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.339,
Antwerp 2020, Belgium
e-mail: adriaan.campo@ua.ac.be
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.339,
Antwerp 2020, Belgium
e-mail: adriaan.campo@ua.ac.be
Matthew D. McGarry
Thayer School of Engineering Dartmouth,
14 Engineering Drive,
Hanover, NH 03755
e-mail: matthew.d.mcgarry@dartmouth.edu
14 Engineering Drive,
Hanover, NH 03755
e-mail: matthew.d.mcgarry@dartmouth.edu
Thomas Panis
Radiology Department,
University Hospital of Brussels,
UZ Brussel, Campus Jette, Laarbeeklaan 101,
Brussels B-1090, Belgium
e-mail: Thomas.panis@gmail.com
University Hospital of Brussels,
UZ Brussel, Campus Jette, Laarbeeklaan 101,
Brussels B-1090, Belgium
e-mail: Thomas.panis@gmail.com
Joris Dirckx
Laboratory of Biomedical Physics,
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.342,
Antwerp 2020, Belgium
e-mail: joris.dirckx@ua.ac.be
Antwerp University,
Campus Groenenborger,
Groenenborgerlaan 171 G.U.342,
Antwerp 2020, Belgium
e-mail: joris.dirckx@ua.ac.be
Elisa Konofagou
Ultrasound Elasticity Imaging Laboratory,
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032
e-mail: ek2191@columbia.edu
Columbia University,
Columbia University Medical Campus,
630 West 168th Street,
Physicians & Surgeons 19-418,
New York, NY 10032
e-mail: ek2191@columbia.edu
1Corresponding author.
Manuscript received April 9, 2018; final manuscript received December 3, 2018; published online January 31, 2019. Assoc. Editor: Jonathan Vande Geest.
J Biomech Eng. Mar 2019, 141(3): 031011 (9 pages)
Published Online: January 31, 2019
Article history
Received:
April 9, 2018
Revised:
December 3, 2018
Citation
Campo, A., McGarry, M. D., Panis, T., Dirckx, J., and Konofagou, E. (January 31, 2019). "Effect of Local Neck Anatomy on Localized One-Dimensional Measurements of Arterial Stiffness: A Finite-Element Model Study." ASME. J Biomech Eng. March 2019; 141(3): 031011. https://doi.org/10.1115/1.4042435
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