Abstract

This study presents a novel technique to measure the motion of the eyelid during blinking. High-speed imaging and digital image correlation (DIC) were employed to monitor the eyelid during blinking in a noninvasive manner. Both spontaneous and reflex blinks were studied. A black liquid eyeliner was used to generate a speckle pattern on the surface of the eyelid. Facet motion captured through a DIC analysis software generated kinematic data for each blink. Calculations using this dataset yielded information on the duration of the blink, eyelid displacements, and peak eyelid velocities. A consistent dataset quantified the difference between blink types and reinforced the repeatability of this DIC analysis method to measure the kinematics of blinking.

References

1.
Avisar
,
I.
,
Nahum
,
Y.
,
Mimouni
,
M.
,
Kremer
,
I.
, and
Malhotra
,
R.
,
2020
, “
Oculoplastic Aspects of Ocular Surface Disease and Their Management
,”
Surv. Ophthalmol.
,
65
(
3
), pp.
312
322
.10.1016/j.survophthal.2019.11.003
2.
Lu
,
R.
,
Huang
,
R.
,
Li
,
K.
,
Zhang
,
X.
,
Yang
,
H.
,
Quan
,
Y.
, and
Li
,
Q.
,
2014
, “
The Influence of Benign Essential Blepharospasm on Dry Eye Disease and Ocular Inflammation
,”
Am. J. Ophthalmol.
,
157
(
3
), pp.
591
597.
10.1016/j.ajo.2013.11.014
3.
Mastrota
,
K. M.
,
2008
, “
Impact of Floppy Eyelid Syndrome in Ocular Surface and Dry Eye Disease
,”
Optom. Vis. Sci.
,
85
(
9
), pp.
814
816
.10.1097/OPX.0b013e3181852777
4.
Sohrab
,
M.
,
Abugo
,
U.
,
Grant
,
M.
, and
Merbs
,
S.
,
2015
, “
Management of the Eye in Facial Paralysis
,”
Facial Plast. Surg.
,
31
(
2
), pp.
140
144
.10.1055/s-0035-1549292
5.
Buzzi
,
M.
,
Giannaccare
,
G.
,
Cennamo
,
M.
,
Bernabei
,
F.
,
Rothschild
,
P. R.
,
Vagge
,
A.
,
Scorcia
,
V.
, and
Mencucci
,
R.
,
2022
, “
Ocular Surface Features in Patients With Parkinson Disease on and Off Treatment: A Narrative Review
,”
Life (Basel)
,
12
(
12
), p.
2141
.10.3390/life12122141
6.
Ruiz-Lozano
,
R. E.
,
Azar
,
N. S.
,
Mousa
,
H. M.
,
Quiroga-Garza
,
M. E.
,
Komai
,
S.
,
Wheelock-Gutierrez
,
L.
,
Cartes
,
C.
, and
Perez
,
V. L.
,
2023
, “
Ocular Surface Disease: A Known yet Overlooked Side Effect of Topical Glaucoma Therapy
,”
Front. Toxicol.
,
5
, p.
1067942
.10.3389/ftox.2023.1067942
7.
Ogawa
,
K.
,
Okazaki
,
M.
,
Mori
,
H.
,
Hidaka
,
T.
,
Tomioka
,
Y.
,
Tanaka
,
K.
,
Uemura
,
N.
, and
Akiyama
,
M.
,
2022
, “
Comparative Blink Analysis in Patients With Established Facial Paralysis Using High-Speed Video Analysis
,”
J. Craniofac. Surg.
,
33
(
3
), pp.
797
802
.10.1097/SCS.0000000000008326
8.
Kimura
,
N.
,
Watanabe
,
A.
,
Suzuki
,
K.
,
Toyoda
,
H.
,
Hakamata
,
N.
,
Fukuoka
,
H.
,
Washimi
,
Y.
,
Arahata
,
Y.
,
Takeda
,
A.
, et al.,
2017
, “
Measurement of Spontaneous Blinks in Patients With Parkinson's Disease Using a New High-Speed Blink Analysis System
,”
J. Neurol. Sci.
,
380
, pp.
200
204
.10.1016/j.jns.2017.07.035
9.
Solyman
,
O.
,
Tharwat
,
A.
,
El Sabbagh
,
A. S.
,
Allen
,
R. C.
, and
Elessawy
,
K. B.
,
2023
, “
Eyelid Blink Lagophthalmos and Blinking Velocity Changes After External Transcutaneous Dacrocystorhinostomy: A Prospective Study
,”
Am. J. Ophthalmol.
,
245
, pp.
81
85
.10.1016/j.ajo.2022.08.026
10.
Espinosa
,
J.
,
Domenech
,
B.
,
Vázquez
,
C.
,
Pérez
,
J.
, and
Mas
,
D.
,
2018
, “
Blinking Characterization From High Speed Video Records: Application to Biometric Authentication
,”
PLoS One
,
13
(
5
), p.
e0196125
.10.1371/journal.pone.0196125
11.
Su
,
Y.
,
Liang
,
Q.
,
Su
,
G.
,
Wang
,
N.
,
Baudouin
,
C.
, and
Labbé
,
A.
,
2018
, “
Spontaneous Eye Blink Patterns in Dry Eye: Clinical Correlations
,”
Invest. Ophthalmol. Vis. Sci.
,
59
(
12
), pp.
5149
–51
56
.10.1167/iovs.18-24690
12.
Mak
,
F. H.
,
Harker
,
A.
,
Kwon
,
K. A.
,
Edirisinghe
,
M.
,
Rose
,
G. E.
,
Murta
,
F.
, and
Ezra
,
D. G.
,
2016
, “
Analysis of Blink Dynamics in Patients With Blepharoptosis
,”
J. R. Soc. Interface
,
13
(
116
), p.
20150932
.10.1098/rsif.2015.0932
13.
Kato
,
H.
,
Yokoi
,
N.
,
Watanabe
,
A.
,
Komuro
,
A.
,
Sonomura
,
Y.
,
Sotozono
,
C.
, and
Kinoshita
,
S.
,
2022
, “
Clinical Factors for Determining the Severity of Lid Wiper Epitheliopathy in Dry Eye
,”
Cornea
,
41
(
5
), pp.
545
551
.10.1097/ICO.0000000000002879
14.
Oganov
,
A.
,
Yazdanpanah
,
G.
,
Jabbehdari
,
S.
,
Belamkar
,
A.
, and
Pflugfelder
,
S.
,
2023
, “
Dry Eye Disease and Blinking Behaviors: A Narrative Review of Methodologies for Measuring Blink Dynamics and Inducing Blink Response
,”
Ocul. Surf.
,
29
, pp.
166
174
.10.1016/j.jtos.2023.05.011
15.
Wang
,
M. T. M.
,
Tien
,
L.
,
Han
,
A.
,
Lee
,
J. M.
,
Kim
,
D.
,
Markoulli
,
M.
, and
Craig
,
J. P.
,
2018
, “
Impact of Blinking on Ocular Surface and Tear Film Parameters
,”
Ocul. Surf.
,
16
(
4
), pp.
424
429
.10.1016/j.jtos.2018.06.001
16.
Tsubota
,
K.
, and
Nakamori
,
K.
,
1995
, “
Effects of Ocular Surface Area and Blink Rate on Tear Dynamics
,”
Arch. Ophthalmol.
,
113
(
2
), pp.
155
158
.10.1001/archopht.1995.01100020037025
17.
Robinson
,
D. A.
,
1963
, “
A Method of Measuring Eye Movement Using a Scleral Search Coil in a Magnetic Field
,”
IEEE Trans. Biomed. Eng.
,
10
, pp.
137
–1
45
.10.1109/TBMEL.1963.4322822
18.
Kaneko
,
K.
, and
Sakamoto
,
K.
,
1999
, “
Evaluation of Three Types of Blinks With the Use of Electro-Oculogram and Electromyogram
,”
Percept. Mot. Skills
,
88
(
3
), pp.
1037
1052
.10.2466/pms.1999.88.3.1037
19.
Sanchis-Jurado
,
V. C.
,
Talens-Estarelles
,
J. J.
,
Esteve-Taboada
,
M.
,
Pons
,
Á.
, and
García-Lázaro
, S.,
2020
, “
Non-Invasive High-Speed Blinking Kinematics Characterization
,”
Graefes Arch. Clin. Exp. Ophthalmol.
,
258
(
12
), pp.
2701
2714
.10.1007/s00417-020-04782-w
20.
DeAngelis
,
K. D.
,
Rider
,
A.
,
Potter
,
W.
,
Jensen
,
J.
,
Fowler
,
B. T.
, and
Fleming
,
J. C.
,
2019
, “
Eyelid Spontaneous Blink Analysis and Age-Related Changes Through High-Speed Imaging
,”
Ophthalmic Plast. Reconstr. Surg.
,
35
(
5
), pp.
487
490
.10.1097/IOP.0000000000001349
21.
Wambier
,
S. P.
,
Ribeiro
,
S. F.
,
Garcia
,
D. M.
,
Brigato
,
R. R.
,
Messias
,
A.
, and
Cruz
,
A. A.
,
2014
, “
Two-Dimensional Video Analysis of the Upper Eyelid Motion During Spontaneous Blinking
,”
Ophthalmic Plast. Reconstr. Surg.
,
30
(
2
), pp.
146
151
.10.1097/IOP.0000000000000031
22.
Kwon
,
K. A.
,
Shipley
,
R. J.
,
Edirisinghe
,
M.
,
Ezra
,
D. G.
,
Rose
,
G.
,
Best
,
S. M.
, and
Cameron
,
R. E.
,
2013
, “
High-Speed Camera Characterization of Voluntary Eye Blinking Kinematics
,”
J. R. Soc. Interface
,
10
(
85
), p.
20130227
.10.1098/rsif.2013.0227
23.
Navascues-Cornago
,
M.
,
Morgan
,
P. B.
,
Maldonado-Codina
,
C.
, and
Read
,
M. L.
,
2020
, “
Characterisation of Blink Dynamics Using a High-Speed Infrared Imaging System
,”
Ophthalmic Physiol. Opt.
,
40
(
4
), pp.
519
–5
28
.10.1111/opo.12694
24.
Espinosa
,
J.
,
Pérez
,
J.
, and
Mas
,
D.
,
2020
, “
Comparative Analysis of Spontaneous Blinking and the Corneal Reflex
,”
R. Soc. Open Sci.
,
7
(
12
), p.
201016
.10.1098/rsos.201016
25.
Valls-Sole
,
J.
,
2019
, “
Spontaneous, Voluntary, and Reflex Blinking in Clinical Practice.
J. Clin. Neurophysiol.
,
36
(
6
), pp.
415
421
.10.1097/WNP.0000000000000561
26.
Sutton
,
M. A.
,
Wolters
,
W. J.
,
Peters
,
W. H.
,
Ranson
,
W. F.
, and
McNeill
,
S. R.
,
1983
, “
Determination of Displacements Using an Improved Digital Correlation Method
,”
Image Vision Comput.
,
1
(
3
), pp.
133
139
.10.1016/0262-8856(83)90064-1
27.
Bruck
,
H. A.
,
McNeill
,
S. R.
,
Sutton
,
M. A.
, and
Peters
,
W. H.
,
1989
, “
Digital Image Correlation Using Newton-Raphson Method of Partial Differential Correction
,”
Exp. Mech.
,
29
(
3
), pp.
261
267
.10.1007/BF02321405
28.
Pan
,
B.
,
Qian
,
K.
,
Xie
,
H.
, and
Asundi
,
A.
,
2009
, “
Two-Dimensional Digital Image Correlation for in-Plane Displacement and Strain Measurement: A Review
,”
Meas. Sci. Technol.
,
20
(
6
), p.
062001
.10.1088/0957-0233/20/6/062001
29.
Hild
,
F.
, and
Roux
,
S.
,
2006
, “
Digital Image Correlation: From Displacement Measurement to Identification of Elastic Properties—a Review
,”
Strain
,
42
, pp.
69
80
.10.1111/j.1475-1305.2006.00258.x
30.
Sakai
,
K.
,
Zhang
,
Y.
,
Yoneyama
,
S.
,
Miyazaki
,
Y.
,
Hanada
,
Y.
,
Nagai
,
Y.
, and
Igarashi
,
T.
,
2020
, “
Evaluating Distribution and Variation of Strains Near Eyes in Blinking Using Digital Image Correlation.
Skin Res. Technol.
,
26
(
5
), pp.
749
756
.10.1111/srt.12867
31.
Mobasher
,
B.
,
2016
, “
Textile Fiber Composites: Testing and Mechanical Behavior
,”
Textile Fibre Composites in Civil Engineering
,
T.
Thanasis, ed.
,
Woodhead Publishing, Sawston, UK
, pp.
101
150
.
32.
Hassan
,
G. M.
,
2021
, “
Deformation Measurement in the Presence of Discontinuities With Digital Image Correlation: A Review
,”
Opt. Lasers Eng.
,
137
, p.
106394
.10.1016/j.optlaseng.2020.106394
33.
Holmes
,
J.
,
Sommacal
,
S.
,
Das
,
R.
,
Stachurski
,
Z.
, and
Compston
,
P.
,
2023
, “
Digital Image and Volume Correlation for Deformation and Damage Characterisation of Fibre-Reinforced Composites: A Review
,”
Compos. Struct.
,
315
, p.
116994
.10.1016/j.compstruct.2023.116994
34.
Bologna
,
M.
,
Agostino
,
R.
,
Gregori
,
B.
,
Belvisi
,
D.
,
Ottaviani
,
D.
,
Colosimo
,
C.
,
Fabbrini
,
G.
, and
Berardelli
,
A.
,
2008
, “
Voluntary, Spontaneous and Reflex Blinking in Patients With Clinically Probable Progressive Supranuclear Palsy
,”
Brain
,
132
(
2
), pp.
502
510
.10.1093/brain/awn317
35.
Lee
,
D.
,
Won
,
I.
,
Bae
,
E. J.
,
Cho
,
C. H.
,
Kim
,
C. M.
,
Kim
,
D. K.
,
Rah
., and
Kim
, Y. O.,
2013
, “
Eyelid Dynamics and Supratarsal Crease Appearance After Double Eyelid Surgery
,”
J. Craniofacial Surg.
,
24
(
3
), pp.
818
821
.10.1097/SCS.0b013e31829028a2
36.
Doane
,
M. G.
,
1980
, “
Interactions of Eyelids and Tears in Corneal Wetting and the Dynamics of the Normal Human Eyeblink
,”
Am. J. Ophthalmol.
,
89
(
4
), pp.
507
516
.10.1016/0002-9394(80)90058-6
37.
Sforza
,
C.
,
Rango
,
M.
,
Galante
,
D.
,
Bresolin
,
N.
, and
Ferrario
,
V. F.
,
2008
, “
Spontaneous Blinking in Healthy Persons: An Optoelectronic Study of Eyelid Motion
,”
Ophthalmic Physiol. Opt.
,
28
(
4
), pp.
345
353
.10.1111/j.1475-1313.2008.00577.x
38.
Godfrey
,
K. J.
,
Wilsen
,
C.
,
Satterfield
,
K.
,
Korn
,
B. S.
, and
Kikkawa
,
D. O.
,
2019
, “
Analysis of Spontaneous Eyelid Blink Dynamics Using a 240 Frames Per Second Smartphone Camera.
Ophthalmic Plast. Reconstr. Surg.
,
35
(
5
), pp.
503
505
.10.1097/IOP.0000000000001356
39.
Paparella
,
G.
,
De Biase
,
A.
,
Cannavacciuolo
,
A.
,
Colella
,
D.
,
Passaretti
,
M.
,
Angelini
,
L.
,
Guerra
,
A.
,
Berardelli
,
A.
, and
Bologna
,
M.
,
2022
, “
Validating a Portable Device for Blinking Analyses Through Laboratory Neurophysiological Techniques
,”
Brain Sci.
,
12
(
9
), p.
1228
.10.3390/brainsci12091228
40.
Osaki
,
M. H.
,
Osaki
,
T. H.
,
Garcia
,
D. M.
,
Osaki
,
T.
,
Gameiro
,
G. R.
,
Belfort
,
R.
, Jr.
, and
Cruz
,
A. A. V.
,
2020
, “
Analysis of Blink Activity and Anomalous Eyelid Movements in Patients With Hemifacial Spasm
,”
Graefes Arch. Clin. Exp. Ophthalmol.
,
258
(
3
), pp.
669
674
.10.1007/s00417-019-04567-w
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