...Katherine D. Kavlock; Aaron S. Goldstein Perfusion bioreactors are a promising in vitro strategy to engineer bone tissue because they supply needed oxygen and nutrients and apply an osteoinductive mechanical stimulus to osteoblasts within large porous three-dimensional scaffolds. Model two...

...Tai-Yi Yuan; Chun-Yuh Huang; Wei Yong Gu The goal of tissue engineering is to use substitutes to repair and restore organ function. Bioreactors are an indispensable tool for monitoring and controlling the unique environment for engineered constructs to grow. However, in order to determine...

...Xiao Bing Chen; Yi Sui; Heow Pueh Lee; Hui Xing Bai; Peng Yu; S. H. Winoto; Hong Tong Low A two-dimensional flow model has been developed to simulate mass transport in a microchannel bioreactor with a porous wall. A two-domain approach, based on the finite volume method, was implemented...

...J. M. Osborne; R. D. O’Dea; J. P. Whiteley; H. M. Byrne; S. L. Waters A three phase model for the growth of a tissue construct within a perfusion bioreactor is examined. The cell population (and attendant extracellular matrix), culture medium, and porous scaffold are treated as distinct phases...

... biomechanics biomedical equipment bioreactors carbon compounds cellular biophysics silicon tissue engineering uniaxial stretch bioreactor scaffold strain Tissue engineering has emerged as a very promising procedure to repair, replace, or regenerate damaged tissues using tissue constructs...

...Liam T. Breen; Peter E. McHugh; Bruce P. Murphy Over the past 25 years, many laboratory based bioreactors have been used to study the cellular response to hemodynamic forces. The vast majority of these studies have focused on the effect of a single isolated hemodynamic force, generally consisting...

... bioreactor in order to obtain results that aid experimental design. The steady-state permeation protocol induces different types of mechanical stimuli. When the specimen is initially homogeneous, it directly induces homogeneous permeation velocities and indirectly induces nonhomogeneous solid matrix shear...

... coculture bioreactors is achieved by having the product of the length ratio and the reaction ratio equal to 1. This condition was used to optimize the mass transfer in the micropatterned system ( Bhatia et al., 1999, “Effect of Cell-Cell Interactions in Preservation of Cellular henotype: Co-Cultivation...

... valve leaflets with respect to the blood flow is one important component of their mechanical environment in vivo. Although different types of bioreactors have been designed to subject cells to shear stress, devices to expose biological tissue are few. In an effort to address this issue, the aim...

...Yan Zeng; Thong-See Lee; Peng Yu; Hong-Tong Low Microchannel bioreactors have applications for manipulating and investigating the fluid microenvironment on cell growth and functions in either single culture or co-culture. This study considers two different types of cells distributed randomly...

...Yan Zeng; Thong-See Lee; Peng Yu; Partha Roy; Hong-Tong Low Microchannel bioreactors have been used in many studies to manipulate and investigate the fluid microenvironment around cells. In this study, substrate concentrations and shear stresses at the base were computed from a three-dimensional...

... on the plate surface are presented. 04 03 2004 01 12 2004 biological techniques biomechanics bioreactors cellular biophysics perturbation techniques fluid oscillations Mechanical stimulation is a significant modulator of cell physiology. There is important evidence that physical...