Fig. 1 Extracorporeal oxygenation via hypothermic peritoneal perfusion of cold PFC. Hypothermia and cold PFC perfusion may increase PFC-to-blood oxygen tension gradient by decreasing venous oxygen tension and increasing oxygen tension of PFC, respectively. These two mechanisms may collectively fac... More about this image found in Extracorporeal oxygenation via hypothermic peritoneal perfusion of cold PFC...

Fig. 2 Mathematical model of oxygenation dynamics in response to mechanical ventilation and peritoneal PFC perfusion. Each box denotes a compartment in which state and volume are defined. The quantities on the arrows denote the rate of O 2 transport. The governing equation pertaining to each comp... More about this image found in Mathematical model of oxygenation dynamics in response to mechanical ventil...

Fig. 3 C-VI method to infer probability density functions of trial-specific and trial-average parameters in the mathematical model by analyzing a dataset including multiple hypoxia trials More about this image found in C-VI method to infer probability density functions of trial-specific and tr...

Fig. 4 Representative example of ( a ) FIO 2 manipulated to induce hypoxia as well as measured versus simulated ( b ) SpO 2 , ( c ) SvO 2 , and ( d ) ETO 2 More about this image found in Representative example of ( a ) FIO 2 manipulated to induce hypoxia as wel...

Fig. 5 PDFs of trial-specific (thin) and trial-average (thick) mathematical model parameters as inferred by the C-VI method. Diagonal entries are the PDFs of individual parameters. Off-diagonal entries are covariances between two mathematical model parameters. Note that all the mathematical model ... More about this image found in PDFs of trial-specific (thin) and trial-average (thick) mathematical model ...

Fig. 6 The effect of hypothermia and peritoneal cold PFC perfusion on ( a ) SpO 2 , ( b ) SvO 2 , ( c ) O 2 diffusion rate between PFC and blood, and ( d ) O 2 diffusion rate between PFC and blood normalized by O 2 consumption, all under hypoxia induced by 15% FIO 2 More about this image found in The effect of hypothermia and peritoneal cold PFC perfusion on ( a ) SpO 2 ...

Fig. 7 The effect of hypothermia (32 °C body temperature) alone, cold (15 °C) PFC perfusion alone, and hypothermic cold PFC perfusion (15 °C PFC at 32 °C body temperature) on SpO 2 , SvO 2 , O 2 diffusion rate between PFC and blood, and O 2 extraction ratio, all under hypoxia induced by 15% FIO ... More about this image found in The effect of hypothermia (32 °C body temperature) alone, cold (15 °C) PFC ...

Fig. 8 The effect of hypothetical changes in the O 2 diffusion coefficient on ( a ) SpO 2 and ( b ) SvO 2 pertaining to normothermic PFC perfusion (37.5 °C PFC at 37.5 °C body temperature) and hypothermic cold PFC perfusion (37.5–15 °C PFC at 32 °C body temperature), all under hypoxia induced b... More about this image found in The effect of hypothetical changes in the O 2 diffusion coefficient on ( a...

Fig. 1 The architecture of the mathematical model. The mathematical model includes (i) a lumped-parameter model of cardiovascular (CV) physiology with autonomic-cardiac regulation mechanisms associated with cardiac output (CO), systemic vascular resistance (SVR), and venous blood volume, integrate... More about this image found in The architecture of the mathematical model. The mathematical model includes...

Fig. 2 Collective variational inference (C-VI) method to derive a virtual patient generator (VPG) by analyzing the data of a cohort of subjects More about this image found in Collective variational inference (C-VI) method to derive a virtual patient ...

Fig. 3 Representative example of the experimental MAP versus MAP replicated by the subject-specific mathematical model in a training subject More about this image found in Representative example of the experimental MAP versus MAP replicated by the...

Fig. 4 MAEs and r values associated with various values of λ used in the LOSO analysis. The optimal value of λ was selected as λ = 250 , which was associated with adequate balance among all the metrics and small regularization cost. For λ > 250 , imbalance in the metri... More about this image found in MAEs and r values associated with various values of λ used in the LOS...

Fig. 5 VPG performance evaluated using subject-replicating VPs in LOSO analysis and blind testing. ( a )–( c ) Cumulative distributions of NMAEs associated with MAP, CO, and SVR (mean±SE). ( d )–( f ) Cumulative distributions of experimental data coverage rates (percentages of experimental data pe... More about this image found in VPG performance evaluated using subject-replicating VPs in LOSO analysis an...

Fig. 6 Representative example of the experimental MAP, CO, and SVR versus subject-replicating VP envelope in a blind testing subject More about this image found in Representative example of the experimental MAP, CO, and SVR versus subject-...

Fig. 1 Sheet metal production by metal peeling More about this image found in Sheet metal production by metal peeling

Fig. 2 Schematic of peeling process, with the inset showing peeling variables and strip geometry More about this image found in Schematic of peeling process, with the inset showing peeling variables and ...